Antibody Engineer Scientist

LausanneFixe2018-10-01Non exigé / Non qualifié
Spring Life Sciences is looking for his client a

Antibody Engineer Scientist

The Role:

• We are seeking an experienced Ph.D. level scientist with a deep understanding of generating recombinant antibodies including classical, fragment and multi-specific formats.
• The Antibody Engineer's mission is to enable the development of innovative molecules as therapeutic and vaccine candidates for the treatment of patients' with neurodegenerative disease.
• The candidate will have the opportunity to participate in cross functional teams focused on the development of biotherapeutic drugs, and to mentor external projects and collaborations.
• The ideal candidate is a highly independent and motivated team player who will foster close cross functional interactions and alignment with colleagues supporting discovery, preclinical and clinical development of the portfolio.

Responsibilities:

• Serve as a source of state-of-the-art scientific knowledge in the field of therapeutic antibodies; exert influence on research direction and the choice of experimental approaches taken
• Utilize cutting edge knowledge and technologies to design and generate recombinant antibodies (e.g. identification of VH/VL sequences, choice of lead sequence, recloning on an appropriate backbone, backmutation analysis, preparation of double gene vectors)
• Design and implement strategies for humanization of mouse/rat antibodies
• Identify and implement innovative technology platforms in the field of therapeutic antibodies
• Record, analyse and communicate scientific data to supervisor/manager and project teams with clear interpretation of results and proposed next steps
• Deliver data that will support filing and execution of patent applications
• Contribute to the new target selection process that is centered on providing innovative approaches to address unmet patient needs
• Participate in project teams and mentor external collaborations
• Take day-to-day managerial responsibility for direct reports
• Maintain high laboratory standards with regard to quality, safety and general laboratory housekeeping

Profile:

• Ph.D. in life sciences (or related discipline)
• Minimum 5-year experience of antibody engineering in a biopharma, setting involved in the drug discovery and target validation process
• Expertise in molecular biology
• Knowledge of manufacturing antibodies
• Supervisory experience
• Strong understanding of the principals of antibody scaffolds
• Strong experience in the use and application of engineering antibodies for clinical use
• Scientific and strategic summaries to working groups and governance committees
• Capability to challenge assumptions and critically interpret data

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La référence de cette offre est JN -092018-293690 - HAID

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